Shelling by government forces in Syria has killed Remi Ochlik, a French photographer, and Marie Colvin, an American-born war correspondent who spent the last two decades reporting from some of the world’s most dangerous conflicts for Britain’s The Sunday Times. The two died in the city of Homs, which is at the heart of uprising against Syrian President Bashar al-Assad.

Colvin and Ochlik were killed when a shell hit the house where they were staying. The U.S. estimates that 5, 400 people have been killed since the Syrian uprising began about 11 months ago.

The latest violence comes as Secretary of State Hillary Clinton heads to London to meet with leaders from the region ahead of a major conference on Syria later this week.

Rupert Murdoch, the chairman and CEO of News Corporation, the parent company of both Fox News Channel and The Sunday Times, released this statement on the death of Marie Colvin:

“Marie had fearlessly covered wars across the Middle East and South Asia for 25 years for ‘The Sunday Times.’ She put her life in danger on many occasions because she was driven by a determination that the misdeeds of tyrants and the suffering of the victims did not go unreported. This was at great personal cost, including the loss of the sight in one eye while covering the civil war in Sri Lanka. This injury did not stop her from returning to even more dangerous assignments. Our immediate thoughts are with her family.”